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Chemical Structure : NSAH
CAS No.: 1099592-35-4
Catalog No.: PC-70217Not For Human Use, Lab Use Only.
Ribonucleotide reductase inhibitor NASH is a nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM.
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|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
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Ribonucleotide reductase inhibitor NASH is a nonnucleoside, competitive, small-molecule inhibitor of human ribonucleotide reductase (hRR) that binds to the large subunit hRRM1 at the catalytic site (C-site) with Kd of 37.4 uM, IC50 of 32 uM.
NASH has twofold IC50 of gemcitabine for growth inhibition of multiple cancer cell lines, while demonstrating little cytotoxicity against normal mobilized peripheral blood progenitor cells.
NASH depresses dGTP and dATP levels in the dNTP pool causing S-phase arrest, providing evidence for RR inhibition in cells.
| M.Wt | 306.321 | |
| Formula | C18H14N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-2-hydroxy-N'-((2-hydroxynaphthalen-1-yl)methylene)benzohydrazide |
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1. Ahmad MF, et al. Proc Natl Acad Sci U S A. 2017 Jul 17. pii: 201620220.
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