NSC 141562 | Probechem Biochemicals

Chemical Structure : NSC 141562

NSC 141562 (NSC141562;NSC-141562)

Catalog No.: PC-60435Not For Human Use, Lab Use Only.

A potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis.

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Biological Activity

A potent small-molecule inhibitor of the MIR155 host gene/miR-155 axis; strongly inhibits mature miR-155 generation in a timedependent manner in U87 and primary GBM cells, reduces the proliferation, migration and invasion, increases the expression of PCDH9 and PCDH7, decreases the expression of mesenchymal transition-associated markers, N-cadherin, vimentin, MMP9 and β-catenin.

Physicochemical Properties

M.Wt	376.302
Formula	C17H22BrN5
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(2-methylquinolin-3-yl)methyl]-3,7-triaza-1-azoniatricyclo[3.3.1.13,7]decane bromide

References

1. Wu X, et al. Neuro Oncol. 2017 Sep 1;19(9):1195-1205.

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NSC 141562 (NSC141562;NSC-141562)

Biological Activity

Physicochemical Properties

References

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