Catalog No.: PC-60597Not For Human Use, Lab Use Only.
NSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities.
NSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities.
NSC 185058 directly inhibits cellular ATG4B activity induced by starvation or rapamycin and suppresses the lipidation of LC3B and autophagosome formation in response to starvation, suppresses Saos-2 osteosarcoma growth in vivo.
NSC 185058 markedly slows tumor growth and provides a significant survival benefit in GBM xenografts combined with radiotherapy.
Physicochemical Properties
M.Wt
215.274
Formula
C11H9N3S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-pyridin-2-ylpyridine-2-carbothioamide
References
1. Akin D, et al. Autophagy. 2014;10(11):2021-35.
2. Huang T, et al. Cancer Cell. 2017 Dec 11;32(6):840-855.e8.
