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NSC23925B

Chemical Structure : NSC23925B

CAS No.: 1369591-04-7

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NSC23925B (NSC 23925b)

Catalog No.: PC-62666Not For Human Use, Lab Use Only.

NSC23925B is a small molecule agent that reverses MDR in cancer cells, reverses MDR in several drug-resistant cell lines expressing P-gp.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NSC23925B is a small molecule agent that reverses MDR in cancer cells, reverses MDR in several drug-resistant cell lines expressing P-gp.
    NSC23925B resensitizes cancer cell lines to paclitaxel, doxorubicin, mitoxantrone, etc.
    NSC23925B significantly enhances in vivo antitumor activity of paclitaxel in MDR xenograft models, without increasing the level of paclitaxel toxicity.

    Physicochemical Properties

    M.Wt 421.362
    Formula C22H26Cl2N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-(2-(4-methoxyphenyl)quinolin-4-yl)((R)-piperidin-2-yl)methanol dihydrochloride

    References

    1. Duan Z, et al. J Med Chem. 2012 Apr 12;55(7):3113-21.

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