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NSC305787

Chemical Structure : NSC305787

CAS No.: 785718-37-8

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NSC305787 (NSC 305787)

Catalog No.: PC-45560Not For Human Use, Lab Use Only.

NSC305787 is a small molecule inhibitor of Ezrin with Kd of 5.85 uM.

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5 mg $258 In stock
10 mg $398 In stock
25 mg $598 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NSC305787 is a small molecule inhibitor of Ezrin with Kd of 5.85 uM.
NSC305787 inhibits ezrin phosphorylation, ezrin-actin interaction and ezrin-mediated motility of osteosarcoma (OS) cells in culture.
NSC305787 inhibits lung metastasis of ezrin-sensitive cells in mice; also inhibits SHIP-1 and SHIP-2.

Physicochemical Properties

M.Wt 445.4245
Formula C25H30Cl2N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Quinolinemethanol, 6,8-dichloro-α-2-piperidinyl-2-tricyclo[3.3.1.13,7]dec-1-yl-

References

1. Bulut G, et al. Oncogene. 2012 Jan 19;31(3):269-81.

2. Russo CM, et al. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5344-8.

3. Çelik H, et al. J Biol Chem. 2016 Jun 17;291(25):13257-70.

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