NSC361563 | DYRK1A inhibitor | Probechem Biochemicals

Chemical Structure : NSC361563

NSC361563 (NSC 361563)

Catalog No.: PC-23353Not For Human Use, Lab Use Only.

NSC361563 is a potent and selective DYRK1A inhibitor with IC50 of 1.38 uM.

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Biological Activity

NSC361563 is a potent and selective DYRK1A inhibitor with IC50 of 1.38 uM.
NSC361563 shows 87% reductions in DYRK1A activity when tested at 10 µM.
NSC361563 dose-dependently reduced tau phosphorylation levels at Ser199/202, Thr181, Thr212, and Thr217.
NSC361563 effectively reduced APP phosphorylation and Aβ42 production.
NSC361563 reversed Aβ oligomer-induced neuronal cell death.

Physicochemical Properties

M.Wt	196.21
Formula	C11H8N4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-phenyl-1H-pyrazolo[3,4-b]pyrazine

References

1. Tu HJ, et al. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2418470.

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NSC361563 (NSC 361563)

Biological Activity

Physicochemical Properties

References

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