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Chemical Structure : NSC 370284
CAS No.: 116409-29-1
Catalog No.: PC-62520Not For Human Use, Lab Use Only.
NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
shows no inhibitory effect on the viability of TET1-low AML (i.e., NB4) cells, function as TET1-transcription inhibitor in TET1-high AMLs and the anti-leukemic effects are TET1-dependent.
| M.Wt | 387.432 | |
| Formula | C21H25NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-(pyrrolidin-1-yl(3,4,5-trimethoxyphenyl)methyl)benzo[d][1,3]dioxol-5-ol |
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1. Jiang X, et al. Nat Commun. 2017 Dec 13;8(1):2099.
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