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NSC37215

Chemical Structure : NSC37215

CAS No.: 6274-87-9

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NSC37215 (NSC 37215)

Catalog No.: PC-26961Not For Human Use, Lab Use Only.

NSC37215 is an effective small molecule inhibitor of three prime repair exonuclease 1 (TREX1) with IC50 of 4.72 uM and 30.32 uM for human and mouse TREX1 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NSC37215 is an effective small molecule inhibitor of three prime repair exonuclease 1 (TREX1) with IC50 of 4.72 uM and 30.32 uM for human and mouse TREX1 respectively.
    NSC37215 exhibits a lower Kd with hTREX1 than that with mTREX1.
    NSC37215 inhibits mTREX1 in binding DNA in EMSA assays, inhibits the nuclease activity of TREX1 by interfering with DNA binding.

    Physicochemical Properties

    M.Wt 484.46
    Formula C24H17N2NaO6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-Naphthalenesulfonic acid, 7-[[4-(benzoylamino)benzoyl]amino]-4-hydroxy-, sodium salt

    References

    1. Xing C, et al. Cancer Res. 2025 Aug 1;85(15):2858-2875.

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