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NSC373981

Chemical Structure : NSC373981

CAS No.: 95455-02-0

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NSC373981 (NSC 373981)

Catalog No.: PC-49195Not For Human Use, Lab Use Only.

NSC373981 (NSC 373981) is a CARD11 G-quadruplex (G4) stabilizing small molecule that downregulates CARD11 gene expression in DLBCL cells.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NSC373981 (NSC 373981) is a CARD11 G-quadruplex (G4) stabilizing small molecule that downregulates CARD11 gene expression in DLBCL cells.
NSC373981 dose-dependent repression of CARD11 mRNA levels in both ABC DLBCL cells, RIVA and HBL1, and the GCB DLBCL cell.
NSC373981 requires nitro-group for CARD11 G-quadruplex (G4) stabilization and repression of CARD11 transcription.
NSC373981 concurrently represses the expression of BCL2 and MYC, two other key oncogenes in DLBCL.

Physicochemical Properties

M.Wt 257.245
Formula C14H11NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-nitronaphtho [2,1-b]furan-1-yl)ethan-1-ol

References

1. Kennith Swafford, et al. Genes (Basel). 2022 Jun 25;13(7):1144.

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