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NSC 377071

Chemical Structure : NSC 377071

CAS No.: 26097-80-3

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NSC 377071 (NSC-377071;NSC377071;Cambendazole)

Catalog No.: PC-60598Not For Human Use, Lab Use Only.

NSC 377071 (NSC-377071, NSC377071, Cambendazole) is a novel ATG4B antagonist that inhibits autophagy, with no effect on mTOR and PI3K activities.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NSC 377071 (NSC-377071, NSC377071, Cambendazole) is a novel ATG4B antagonist that inhibits autophagy, with no effect on mTOR and PI3K activities.
NSC 377071 directly inhibits cellular ATG4B activity induced by starvation or rapamycin and suppresses the lipidation of LC3B and autophagosome formation in response to starvation.
NSC 377071 suppresses Saos-2 osteosarcoma growth in vivo.

Physicochemical Properties

M.Wt 302.352
Formula C14H14N4O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Propan-2-yl N-[2-(1,3-thiazol-4-yl)-3H-benzimidazol-5-yl]carbamate

References

1. Akin D, et al. Autophagy. 2014;10(11):2021-35.

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