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NSC49652

Chemical Structure : NSC49652

CAS No.: 908563-68-8

NSC49652 (NSC 49652, NSC-49652)

Catalog No.: PC-35729Not For Human Use, Lab Use Only.

NSC49652 (NSC 49652) is a functional p75NTR agonist targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells.

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Biological Activity

NSC49652 (NSC 49652) is a functional p75NTR agonist targeting the transmembrane domain (TMD) of death receptor p75NTR with IC50 of 10 uM in AraTM assays, alters the relative conformation of p75NTR TMDs and induces dynamic changes in the full-length receptor in mammalian cells.
NSC49652 induces apoptosis through p75NTR and the JNK pathway in neurons and affects the viability of melanoma cells.
NSC49652 reduces tumor growth and improves survival in human melanoma xenograft model, orally available.

Physicochemical Properties

M.Wt 225.247
Formula C14H11NO2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-1-(2-hydroxyphenyl)-3-(pyridin-3-yl)prop-2-en-1-one

References

1. Goh ETH, et al. Cell Chem Biol. 2018 Oct 1. pii: S2451-9456(18)30302-7.

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