NSC622608 | VISTA inhibitor | Probechem Biochemicals

Chemical Structure : NSC622608

CAS No.: 2593254-90-9

NSC622608 (NSC 622608)

Catalog No.: PC-38145Not For Human Use, Lab Use Only.

NSC622608 (NSC 622608) is the first small-molecule ligand for immune checkpoint VISTA with IC50 of 4.8 uM in FRET assay.

Packing	Price	Stock
10 mg	$138	In stock
25 mg	$218	In stock
50 mg	$358	In stock
100 mg	$558	In stock
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Biological Activity

NSC622608 (NSC 622608) is the first small-molecule ligand for immune checkpoint VISTA with IC50 of 4.8 uM in FRET assay.
NSC622608 disrupts VISTA-VSIG-3 interaction with IC50 of 9.7 uM in ELISA assays.
SPR screening confirmed binding of NSC622608 to VISTA ECD with an estimated KD of 6.2 uM.

Physicochemical Properties

M.Wt	322.239
Formula	C9H12BrN3OS2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-((furan-2-ylmethyl)imino)-N,N-dimethyl-3H-1,2,4-dithiazol-5-amine hydrobromide

References

1. Moustafa T Gabr, et al. J Am Chem Soc. 2020 Sep 23;142(38):16194-16198.

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NSC622608 (NSC 622608)

Biological Activity

Physicochemical Properties

References

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