NSC668394 (NSC 668394) is a small molecule inhibitor of Ezrin, directly bind to ezrin with Kd of 12.59 uM.
NSC668394 inhibits T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels.
NSC668394 inhibits PKC-Ι phosphorylation of recombinant ezrin with IC50 of 8.1 uM.
NSC668394 inhibits ezrin-mediated invasion of K7M2 OS cells, inhibits cell motility during zebrafish and Xenopus embryonic development; also inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung.
