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NSC668394

Chemical Structure : NSC668394

CAS No.: 382605-72-3

NSC668394 (NSC 668394;NSC-668394)

Catalog No.: PC-36052Not For Human Use, Lab Use Only.

NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NSC668394 (NSC 668394) is a small molecule inhibitor of ezrin, directly bind to ezrin with Kd of 12.59 uM.
NSC668394 inhibits T567 phosphorylation and actin binding of endogenous ezrin at 10 μM without altering cellular ezrin levels.
NSC668394 inhibits PKC-Ι phosphorylation of recombinant ezrin with IC50 of 8.1 uM.
NSC668394 inhibits ezrin-mediated invasion of K7M2 OS cells, inhibits cell motility during zebrafish and Xenopus embryonic development; also inhibits ezrin-dependent in vivo OS metastatic growth in mouse lung.

Physicochemical Properties

M.Wt 452.102
Formula C17H12Br2N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-((3,5-dibromo-4-hydroxyphenethyl)amino)quinoline-5,8-dione

References

1. Bulut G, et al. Oncogene. 2012 Jan 19;31(3):269-81.

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