NSC81111 | EGFR inhibitor | Probechem Biochemicals

Chemical Structure : NSC81111

NSC81111 (NSC 81111)

Catalog No.: PC-38118Not For Human Use, Lab Use Only.

NSC81111 is a highly potent EGFR-TK inhibitor with IC50 of 0.15 nM.

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Biological Activity

NSC81111 is a highly potent EGFR-TK inhibitor with IC50 of 0.15 nM; NSC81111 displays stronger antiproliferative activities than erlotinib with IC50 values of <10 uM overexpressed EGFR-TK cancer cell lines: A431 and HeLa.

Physicochemical Properties

M.Wt	308.333
Formula	C19H16O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-Bis(4-methoxyphenyl)-4H-pyran-4-one

References

1. Jiwacharoenchai N, et al. Bioorg Med Chem Lett. 2022 Feb 15;58:128524.

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NSC81111 (NSC 81111)

Biological Activity

Physicochemical Properties

References

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