Chemical Structure : NSYSU-115
CAS No.:
144268-59-7
NSYSU-115
(NSYSU115)
Catalog No.: PC-25304Not For Human Use, Lab Use Only.
NSYSU-115 is a highly potent, selective RSK2 inhibitor with IC50 of 45.5 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NSYSU-115 is a highly potent, selective RSK2 inhibitor with IC50 of 45.5 nM.
NSYSU-115 exhibited exceptional inhibitory effects on RSK2 in a panel of 41 kinases from various human kinome families.
NSYSU-115 reduces cell viability in AsPC-1 cells, with decreases of 11%, 14.3%, 17.4%, and 48.2% at concentrations of 1, 3, 10, and 30 μM, respectively.
NSYSU-115 (0.3 uM) induces significant effects in MIA PaCa-2 cells, NSYSU-115 demonstrates a dose-dependent inhibitory effect on colony formation in the pancreatic cancer cell lines.
NSYSU-115 inhibits phosphorylation and degradation downstream of RSK2 in pancreatic cancer cell lines.
NSYSU-115 exhibits a significant inhibitory effect on vimentin expression in pancreatic cancer cell lines.
Physicochemical Properties
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M.Wt
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270.25
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Formula
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C13H10N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-hydroxy-6-methyl-3-(3-oxo-2,3-dihydro-1,2,4-triazin-6-yl)quinolin-2(1H)-one
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References
1. Chung CH, et al. J Enzyme Inhib Med Chem. 2025 Dec;40(1):2538673.
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