NT-157 |CAS:1384426-12-3 Probechem Biochemicals

Chemical Structure : NT-157

CAS No.: 1384426-12-3

NT-157 (NT157, Tyrphostin NT157)

Catalog No.: PC-42046Not For Human Use, Lab Use Only.

NT-157 (Tyrphostin NT157) is a potential anti-cancer agent and IGF1R signaling inhibitor that targets insulin receptor substrates IRS1/2 to degradation.

Packing	Price	Stock
5 mg	$138	In stock
10 mg	$218	In stock
25 mg	$378	In stock
50 mg	$588	In stock
100 mg		Get quote

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Biological Activity

NT-157 (Tyrphostin NT157) is a potential anti-cancer agent and IGF1R signaling inhibitor that targets insulin receptor substrates IRS1/2 to degradation.
NT-157 dose-dependently suppresses IGF1-stimulated activation of IGF1R Y980 phosphorylation (>60% at 2.5 uM) in LNCaP cells, correlated with enhanced ERK activation and IRS1/2 serine phosphorylation and degradation.
NT-157 suppresses CRPC progression of LNCaP xenografts, and PC3 tumor growth alone and combination with docetaxel.

Physicochemical Properties

M.Wt	412.2551
Formula	C16H14BrNO5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	2-Propenethioamide, 3-(3-bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]-, (2E)-

References

1. Ibuki N, et al. Mol Cancer Ther. 2014 Dec;13(12):2827-39.

2. Reuveni H, et al. Cancer Res. 2013 Jul 15;73(14):4383-94.

3. Sanchez-Lopez E, et al. Oncogene. 2016 May 19;35(20):2634-44.

NT-157 (NT157, Tyrphostin NT157)

Biological Activity

Physicochemical Properties

References

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