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NT-157

Chemical Structure : NT-157

CAS No.: 1384426-12-3

NT-157 (NT157, Tyrphostin NT157)

Catalog No.: PC-42046Not For Human Use, Lab Use Only.

NT-157 (Tyrphostin NT157) is a potential anti-cancer agent and IGF1R signaling inhibitor that targets insulin receptor substrates IRS1/2 to degradation.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NT-157 (Tyrphostin NT157) is a potential anti-cancer agent and IGF1R signaling inhibitor that targets insulin receptor substrates IRS1/2 to degradation.
NT-157 dose-dependently suppresses IGF1-stimulated activation of IGF1R Y980 phosphorylation (>60% at 2.5 uM) in LNCaP cells, correlated with enhanced ERK activation and IRS1/2 serine phosphorylation and degradation.
NT-157 suppresses CRPC progression of LNCaP xenografts, and PC3 tumor growth alone and combination with docetaxel.

Physicochemical Properties

M.Wt 412.2551
Formula C16H14BrNO5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 30 mg/mL

Chemical Name/SMILES

2-Propenethioamide, 3-(3-bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]-, (2E)-

References

1. Ibuki N, et al. Mol Cancer Ther. 2014 Dec;13(12):2827-39.

2. Reuveni H, et al. Cancer Res. 2013 Jul 15;73(14):4383-94.

3. Sanchez-Lopez E, et al. Oncogene. 2016 May 19;35(20):2634-44.

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