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Chemical Structure : NT-157
CAS No.: 1384426-12-3
Catalog No.: PC-42046Not For Human Use, Lab Use Only.
A novel potential anti-cancer agent and IGF1R signaling inhibitor that targets insulin receptor substrates IRS1/2 to degradation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $168 | In stock | |
| 10 mg | $248 | In stock | |
| 25 mg | $480 | In stock | |
| 50 mg | $760 | In stock |
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A novel potential anti-cancer agent and IGF1R signaling inhibitor that targets insulin receptor substrates IRS1/2 to degradation; dose-dependently suppresses IGF1-stimulated activation of IGF1R Y980 phosphorylation (>60% at 2.5 uM) in LNCaP cells, correlated with enhanced ERK activation and IRS1/2 serine phosphorylation and degradation; suppresses CRPC progression of LNCaP xenografts, and PC3 tumor growth alone and combination with docetaxel.
| M.Wt | 412.2551 | |
| Formula | C16H14BrNO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
2-Propenethioamide, 3-(3-bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]-, (2E)- |
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1. Ibuki N, et al. Mol Cancer Ther. 2014 Dec;13(12):2827-39.
2. Reuveni H, et al. Cancer Res. 2013 Jul 15;73(14):4383-94.
3. Sanchez-Lopez E, et al. Oncogene. 2016 May 19;35(20):2634-44.
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