Chemical Structure : NT-a9
CAS No.:
2071279-81-5
NT-a9
Catalog No.: PC-27769Not For Human Use, Lab Use Only.
NT-a9 is an analogue of isavuconazole with strong antifungal activities in vitro and in vivo, shows a wide range of activities against several pathogenic fungi in vitro, including Cryptococcus neoformans, Cryptococcus gattii, Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, and Candida parapsilosis with MICs of 0.002-1 ug/mL.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NT-a9 is an analogue of isavuconazole with strong antifungal activities in vitro and in vivo, shows a wide range of activities against several pathogenic fungi in vitro, including Cryptococcus neoformans, Cryptococcus gattii, Candida albicans, Candida krusei, Candida tropicalis, Candida glabrata, and Candida parapsilosis with MICs of 0.002-1 ug/mL.
NT-a9 exhibits excellent efficacy against C. neoformans, with a MIC as low as 0.002 ug/mL.
NT-a9 treatment resulted in changes in the sterol contents in C. neoformans, similarly to fluconazole.
NT-a9 significantly prolonged the survival times of mice compared with the survival times of the control group or the isavuconazole-, fluconazole-, or amphotericin B-treated groups.
NT-a9 also significantly reduced the fungal burdens in brains and lungs, while fluconazole and amphotericin B only reduced the fungal burden in lungs.
Physicochemical Properties
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M.Wt
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480.40
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Formula
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C22H17F5N4O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2R,3R)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-(3-(4-(trifluoromethoxy)phenyl)isoxazol-5-yl)butan-2-ol
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References
1. Lu RY, et al. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01628-19.
2. Zhu S, et al. Antimicrob Agents Chemother. 2026 Aug 5:e0076826.
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