NT150 | NTSR2 agonist | Probechem Biochemicals

Chemical Structure : NT150

NT150 (NT-150)

Catalog No.: PC-27369Not For Human Use, Lab Use Only.

NT150 (NT-150) is a potent, selective metabolically stable neurotensin receptor 2 (NTS2, NTSR2) agonist with Ki of 2.8 nM, has 22,000-fold selectivity over NTSR1.

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Biological Activity

NT150 (NT-150) is a potent, selective metabolically stable neurotensin receptor 2 (NTS2, NTSR2) agonist with Ki of 2.8 nM, has 22,000-fold selectivity over NTSR1.
NT150 reproduced the beneficial effects of NTS in cultured human and murine cells and ameliorated cardiac remodeling and dysfunction in both transverse aortic constriction (TAC) and myocardial infarction (MI).
NT150 induced cGMP production and suppressed prohypertrophic signaling in freshly isolated cardiac tissues from patients with heart failure.

Physicochemical Properties

M.Wt	817.05
Formula	C40H68N10O8
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-hydroxyphenethyl)-N-methyl-L-arginyl-L-lysyl-L-prolylglycyl-L-isoleucyl-L-leucine

References

1. Shiva N, et al. Sci Transl Med. 2026 Jul;18(856):eaea9877.

2. Cornelia Held, et al. ChemMedChem. 2013 Jan;8(1):75-81.

NT150 (NT-150)

Biological Activity

Physicochemical Properties

References

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