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NTRC-824

Chemical Structure : NTRC-824

CAS No.: 1623002-61-8

NTRC-824 (NTRC824)

Catalog No.: PC-22266Not For Human Use, Lab Use Only.

NTRC-824 is the first nonpeptide, selective antagonist of neurotensin receptor type 2 (NTS2/NTSR2) with IC50 of 32 nM in FLIPR assays, binding Ki of 202 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NTRC-824 is the first nonpeptide, selective antagonist of neurotensin receptor type 2 (NTS2/NTSR2) with IC50 of 32 nM in FLIPR assays, binding Ki of 202 nM.
NTRC-824 displays no significant affinity for NTS1 (Ki>30 uM).

Physicochemical Properties

M.Wt 553.55
Formula C25H26F3N3O6S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine

References

1. Thomas JB, et al. J Med Chem. 2014 Sep 11;57(17):7472-7.

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