NU9056 (NU 9056) is a specific Tip60 (KAT5) histone acetyltransferase inhibitor with IC50 of <2 uM.
NU9056 displays 16.5-, 29- and >50-fold for selectivity for Tip60 over PCAF, p300 and GCN5, respectively.
NU9056 (0-40 uM) decreased levels of acetylated histone H4K16, H3K14 and H4K8, targets for Tip60-mediated acetylation in treated LNCaP cells, also decreased acetylated tubulin in LNCaP cells (24 µM NU9056, 24 hours).
NU9056 reduces PSA and p53 protein levels, reduces LNCaP cell survival by inducing apoptosis, inhibits Tip60 accumulation and ATM phosphorylation in response to ionising radiation.
Physicochemical Properties
M.Wt
232.352
Formula
C6H4N2S4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
1,2-bis(isothiazol-5-yl)disulfan
References
1. Coffey K, et al. PLoS One. 2012;7(10):e45539.
2. Tan CS, et al. Mol Neurobiol. 2016 Aug;53(6):3854-3872.
3. Parira T, et al. Sci Rep. 2017 Sep 11;7(1):11236.
4. Simpson S, et al. Front Microbiol. 2018 Apr 24;9:788.
