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Chemical Structure : NUC-7738
Catalog No.: PC-49549Not For Human Use, Lab Use Only.
NUC-7738 is a ProTide and 5'-aryloxy phosphoramidate prodrug of 3'-Deoxyadenosine (3'-dA, Cordycepin), NUC-7738 is an effective anticancer drug in a panel of solid and hematological cancer cell lines.
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NUC-7738 is a ProTide and 5'-aryloxy phosphoramidate prodrug of 3'-Deoxyadenosine (3'-dA, Cordycepin), NUC-7738 is an effective anticancer drug in a panel of solid and hematological cancer cell lines.
ProTide is comprised of a nucleoside fused to a protective phosphoramidate cap, NUC-7738 is capable of releasing active 3′-dAMP into cells where it is rapidly converted to the active species 3′-dATP.
NUC-7738 also shows preferential cytotoxic effects on leukemic stem cells.
Unlike 3'-dA, the activity of NUC-7738 is independent of hENT1 and kinase activity, NUC-7738 is resistant to ADA metabolic deactivation.
NUC-7738 downregulate genes involved in cell survival (PI3K-AKT-MTOR, NOTCH, or WNT-Beta-Catenin Signaling), cell division (Mitotic Spindle, G2M Checkpoint), and DNA repair (UV-response_U or DNA Repair).
NUC-7738 overcomes the cancer resistance mechanisms that limit the activity of 3'-dA.
| M.Wt | 568.527 | |
| Formula | C26H29N6O7P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Serpi M, et al. J Med Chem. 2022 Dec 8;65(23):15789-15804.
2. Schwenzer H, et al. Clin Cancer Res. 2021 Dec 1;27(23):6500-6513.
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