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Chemical Structure : NUCC-0200590
Catalog No.: PC-38762Not For Human Use, Lab Use Only.
NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo.
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NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo.
NUCC-0200590 (5 uM) disrupts TRIP8b mediated HCN channel regulation in HEK cells.
NUCC-0200590 (15 uM) reduces sag ratio in CA1 pyramidal neurons of mouse brain slices.
NUCC-0200590 limits dendritic expression of HCN channels in CA1 region of the hippocampus.
| M.Wt | 482.00 | |
| Formula | C27H29ClFN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ye Han, et al. J Biol Chem Available online 24 May 2022, 102069
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