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NUCC-0200590

Chemical Structure : NUCC-0200590

CAS No.: 1060461-67-7

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NUCC-0200590 (NUCC0200590)

Catalog No.: PC-38762Not For Human Use, Lab Use Only.

NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NUCC-0200590 is a small-molecule inhibitor of the TRIP8b-HCN interaction with IC50 of 7.0 uM in AlphaScreen assays, effectively disrupts the TRIP8b-HCN interaction in vitro and in vivo.
    NUCC-0200590 (5 uM) disrupts TRIP8b mediated HCN channel regulation in HEK cells.
    NUCC-0200590 (15 uM) reduces sag ratio in CA1 pyramidal neurons of mouse brain slices.
    NUCC-0200590 limits dendritic expression of HCN channels in CA1 region of the hippocampus.

    Physicochemical Properties

    M.Wt 482.00
    Formula C27H29ClFN3O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-chlorobenzyl)-2-((4'-fluoro-3-((4-methylpiperazin-1-yl)methyl)-[1,1'-biphenyl]-4-yl)oxy)acetamide

    References

    1. Ye Han, et al. J Biol Chem Available online 24 May 2022, 102069

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