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Chemical Structure : NV-5440
Catalog No.: PC-20247Not For Human Use, Lab Use Only.
NV-5440 (NV5440) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 70 nM, directly targets GLUT-1 with Ki of 69.3 nM.
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NV-5440 (NV5440) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 70 nM, directly targets GLUT-1 with Ki of 69.3 nM.
NV-5440 shows no substantial off-target activity (>75% inhibition at 10 μM) in a panel of kinases.
NV-5440 inhibits glucose uptake inhibition with IC50 of 36 and 140 nM in MCF7 and HUVECs, respectively.
NV-5440 showspotent inhibition of glucose uptake by GLUT1 at 8 nM, shows significantly less inhibition of glucose uptake by both GLUT3 and GLUT4, with IC50 values of 270 and 390 nM, respectively.
NV-5440 acts as a potent inhibitor of glycolysis at multiple points in the glycolysis pathway.
| M.Wt | 572.73 | |
| Formula | C31H36N6O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kang SA, et al. Cell Chem Biol. 2019 Sep 19;26(9):1203-1213.e13.
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