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Chemical Structure : NV-6297
Catalog No.: PC-20248Not For Human Use, Lab Use Only.
NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1.
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NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1.
NV-6297 shows improved pharmacokinetics and oral bioavailability compared with NV-5440.
NV-6297 potently inhibits glucose uptake in MCF7 cells with IC50 of 0.06 uM.
| M.Wt | 587.74 | |
| Formula | C31H37N7O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kang SA, et al. Cell Chem Biol. 2019 Sep 19;26(9):1203-1213.e13.
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