Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NV-6297
Catalog No.: PC-20248Not For Human Use, Lab Use Only.
NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1.
NV-6297 shows improved pharmacokinetics and oral bioavailability compared with NV-5440.
NV-6297 potently inhibits glucose uptake in MCF7 cells with IC50 of 0.06 uM.
| M.Wt | 587.74 | |
| Formula | C31H37N7O3S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Kang SA, et al. Cell Chem Biol. 2019 Sep 19;26(9):1203-1213.e13.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
