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NVP-ADW742

Chemical Structure : NVP-ADW742

CAS No.: 475488-23-4

NVP-ADW742 (ADW742;GSK 552602A)

Catalog No.: PC-42487Not For Human Use, Lab Use Only.

NVP-ADW742 is a selective IGF-1R kinase inhibitor that with IC50 of 0.17 uM in in cellular autophosphorylation assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NVP-ADW742 is a selective IGF-1R kinase inhibitor that with IC50 of 0.17 uM in in cellular autophosphorylation assays.
NVP-ADW742 has >16-fold more potent inhibitory effect against IGF-1R than InsR.
NVP-ADW742 has no activity for HER2, PDGFR, VEGFR-2, Bcr-Abl p210, and c-Kit.
NVP-ADW742 has in vitro activity against diverse tumor cell types (particularly multiple myeloma) and significant antitumor activity in an orthotopic xenograft MM model.

Physicochemical Properties

M.Wt 453.5786
Formula C28H31N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-[3-(phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-

References

1. Mitsiades CS, et al. Cancer Cell. 2004 Mar;5(3):221-30.

2. Warshamana-Greene GS, et al. Mol Cancer Ther. 2004 May;3(5):527-35.

3. Warshamana-Greene GS, et al. Clin Cancer Res. 2005 Feb 15;11(4):1563-71.

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