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Chemical Structure : NVP-ADW742
CAS No.: 475488-23-4
Catalog No.: PC-42487Not For Human Use, Lab Use Only.
NVP-ADW742 is a selective IGF-1R kinase inhibitor that with IC50 of 0.17 uM in in cellular autophosphorylation assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $318 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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NVP-ADW742 is a selective IGF-1R kinase inhibitor that with IC50 of 0.17 uM in in cellular autophosphorylation assays.
NVP-ADW742 has >16-fold more potent inhibitory effect against IGF-1R than InsR.
NVP-ADW742 has no activity for HER2, PDGFR, VEGFR-2, Bcr-Abl p210, and c-Kit.
NVP-ADW742 has in vitro activity against diverse tumor cell types (particularly multiple myeloma) and significant antitumor activity in an orthotopic xenograft MM model.
| M.Wt | 453.5786 | |
| Formula | C28H31N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 5-[3-(phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]- |
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1. Mitsiades CS, et al. Cancer Cell. 2004 Mar;5(3):221-30.
2. Warshamana-Greene GS, et al. Mol Cancer Ther. 2004 May;3(5):527-35.
3. Warshamana-Greene GS, et al. Clin Cancer Res. 2005 Feb 15;11(4):1563-71.
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