Catalog No.: PC-42158Not For Human Use, Lab Use Only.
NVP-AEE788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.
NVP-AEE788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.
NVP-AEE788 (AEE788) inhibits growth factor-induced EGFR and ErbB2 phosphorylation in cells with IC50 of 11 and 220 nM, respectively.
NVP-AEE788 (AEE788) demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines.
NVP-AEE788 (AEE788) shows antitumor and antiangiogenic activity in vivo.
