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NVP-AEW541

Chemical Structure : NVP-AEW541

CAS No.: 475489-16-8

NVP-AEW541 (AEW-541;AEW541;AEW 541;NVP AEW541)

Catalog No.: PC-45879Not For Human Use, Lab Use Only.

NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NVP-AEW541 (AEW-541, AEW541) is a potent, and selective inhibitor of IGF-1R with IC50 of 86 nM.
NVP-AEW541 shows weak activity for closely related InsR (IC50=2.3 uM).
NVP-AEW541 inhibits IGF-IR autophosphorylation and abrogates IGF-I-mediated survival and colony formation in soft agar.
NVP-AEW541 inhibits IGF-IR signaling in tumor xenografts and significantly reduces the growth of IGF-IR-driven fibrosarcomas in vivo; orally bioavailable.

Physicochemical Properties

M.Wt 439.5521
Formula C27H29N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
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Solubility

DMSO: ≥ 51 mg/mL

Chemical Name/SMILES

7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 7-[cis-3-(1-azetidinylmethyl)cyclobutyl]-5-[3-(phenylmethoxy)phenyl]-

References

1. García-Echeverría C, et al. Cancer Cell. 2004 Mar;5(3):231-9.

2. Scotlandi K, et al. Cancer Res. 2005 May 1;65(9):3868-76.

3. Tanno B, et al. Clin Cancer Res. 2006 Nov 15;12(22):6772-80.

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