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NVP-QAV680

Chemical Structure : NVP-QAV680

CAS No.: 872365-16-7

NVP-QAV680 (QAV-680)

Catalog No.: PC-20091Not For Human Use, Lab Use Only.

NVP-QAV680 (QAV680) is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM and IC50 of 147 nM in 3H-PGD2 filtration binding assays and cAMP whole cell assays, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NVP-QAV680 (QAV680) is a potent and selective CRTh2 receptor antagonist with Ki of 36 nM and IC50 of 147 nM in 3H-PGD2 filtration binding assays and cAMP whole cell assays, respectively.
    NVP-QAV680 displays no significant activities against a panel of prostanoid receptors and related eicosanoid targets at 10 uM.
    NVP-QAV680 inhibits DK-PGD2 induced IL-5 and IL-13 from primary cultured human CD4+ Th2 lymphocytes with IC50 of 52 and 25 nM, respectively.
    NVP-QAV680 (10 mg/kg, p.o.) inhibits DK-PGD2-induced pulmonary eosinophilia in Sprague-Dawley rats.

    Physicochemical Properties

    M.Wt 358.41
    Formula C18H18N2O4S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(2-methyl-1-(4-(methylsulfonyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid

    References

    1. Sandham DA, et al. Bioorg Med Chem. 2013 Nov 1;21(21):6582-91.

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