NVP-TAE 684 (TAE684) is a highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays.
NVP-TAE 684 (TAE684) exhibits no significant cross-reactivity against other kinases.
NVP-TAE 684 (TAE684) blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 2-10 nM, inhibits phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.
NVP-TAE 684 (TAE684) suppresses lymphomagenesis in in vivo models.
