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Chemical Structure : NVP-TAE 684
CAS No.: 761439-42-3
Catalog No.: PC-42437Not For Human Use, Lab Use Only.
NVP-TAE 684 (TAE684) is a highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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NVP-TAE 684 (TAE684) is a highly potent and selective, orally available ALK inhibitor with IC50 of 3 nM in cell-free assays.
NVP-TAE 684 (TAE684) exhibits no significant cross-reactivity against other kinases.
NVP-TAE 684 (TAE684) blocks the growth of ALCL-derived and ALK-dependent cell lines with IC50 2-10 nM, inhibits phosphorylation of NPM-ALK and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.
NVP-TAE 684 (TAE684) suppresses lymphomagenesis in in vivo models.
| M.Wt | 614.2017 | |
| Formula | C30H40ClN7O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2,4-Pyrimidinediamine, 5-chloro-N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]- |
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1. Galkin AV, et al. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5.
2. Koivunen JP, et al.
3. George RE, et al. Nature. 2008 Oct 16;455(7215):975-8.
4. McDermott U, et al. Cancer Res. 2008 May 1;68(9):3389-95.
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