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NVS-CRF38

Chemical Structure : NVS-CRF38

CAS No.: 1207258-55-6

NVS-CRF38 (NVS-CRF 38;NVS-CRF-38)

Catalog No.: PC-42988Not For Human Use, Lab Use Only.

NVS-CRF38 is a potent, selective, orally bioavailable corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50 of 70 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NVS-CRF38 is a potent, selective, orally bioavailable corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50 of 70 nM.

    Physicochemical Properties

    M.Wt 351.4023
    Formula C19H21N5O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Pyrazolo[5,1-b]oxazole, 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethyl-

    References

    1. Stringer RA, et al. Xenobiotica. 2014 Oct;44(10):902-12.

    2. Stringer RA, et al. Drug Metab Dispos. 2014 May;42(5):954-62.

    3. Stringer RA, et al. Drug Metab Dispos. 2014 Jul;42(7):1117-24.

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