NVS-MELK8a (MELK8a) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM.
NVS-MELK8a exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM).
NVS-MELK8a exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content.
