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NVS-MELK8a

Chemical Structure : NVS-MELK8a

CAS No.: 1922153-17-0

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NVS-MELK8a (MELK inhibitor)

Catalog No.: PC-20606Not For Human Use, Lab Use Only.

NVS-MELK8a (MELK8a) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM.

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5 mg $198 In stock
10 mg $298 In stock
25 mg $428 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

NVS-MELK8a (MELK8a) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM.
NVS-MELK8a exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM).
NVS-MELK8a exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content.

Physicochemical Properties

M.Wt 432.57
Formula C25H32N6O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Piperazine, 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]-

References

1. Touré BB, et al. J Med Chem. 2016 May 26;59(10):4711-23.

2. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.

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