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Chemical Structure : NVS-MELK8a
CAS No.: 1922153-17-0
Catalog No.: PC-20606Not For Human Use, Lab Use Only.
NVS-MELK8a (MELK8a) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $198 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | $428 | In stock | |
| 100 mg | Get quote |
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NVS-MELK8a (MELK8a) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM.
NVS-MELK8a exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM).
NVS-MELK8a exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content.
| M.Wt | 432.57 | |
| Formula | C25H32N6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Piperazine, 1-methyl-4-[4-[4-[3-(4-piperidinylmethoxy)-4-pyridinyl]-1H-pyrazol-1-yl]phenyl]- |
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1. Touré BB, et al. J Med Chem. 2016 May 26;59(10):4711-23.
2. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693.
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