Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : NVS-PAK1-1
CAS No.: 1783816-74-9
Catalog No.: PC-49534Not For Human Use, Lab Use Only.
NVS-PAK1-1 is a potent, selective and allosteric inhibitor of PAK1 with IC50 of 5 nM, potently inhibits PAK1 phosphorylation in vitro and in vivo.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $268 | In stock | |
| 50 mg | $438 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
NVS-PAK1-1 is a potent, selective and allosteric inhibitor of PAK1 with IC50 of 5 nM, potently inhibits PAK1 phosphorylation in vitro and in vivo.
NVS-PAK1-1 is almost 100× more selective for PAK1 than PAK2.
NVS-PAK1-1 potently inhibited PAK1 autophosphorylation in MS02 cells, and reduced the proliferation of MS02 and HEI-193 cells with an IC50 of 4.7 and 6.2 μM, respectively.
NVS PAK1-1 (30 mg/kg) reduces the average dorsal root ganglia (DRG) size in Nf2-cKO mice.
| M.Wt | 479.932 | |
| Formula | C23H25ClF3N5O | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide |
|
1. Chudi O Ndubaku, et al. ACS Med Chem Lett. 2015 Oct 31;6(12):1241-6.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
