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Chemical Structure : NXC736
Catalog No.: PC-21440Not For Human Use, Lab Use Only.
NXC736 (SLB736) is a selective functional antagonist for type 4 sphingosine-1-phosphate receptor (S1P4 receptor, S1P4R), has immunomodulatory and anti-fibrotic effects.
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NXC736 (SLB736) is a selective functional antagonist for type 4 sphingosine-1-phosphate receptor (S1P4 receptor, S1P4R), has immunomodulatory and anti-fibrotic effects.
NXC736 (SLB736) selectively binds to S1P1 and S1P4.
NXC736 (SLB736) inhibits inflammasome activation by interfering with the NLRP3-ASC-cleaved caspase-1 interaction, thereby reducing the expression of IL-1β and blocking the fibrotic pathway.
NXC736 (SLB736) is a potent therapeutic agent against radiation-induced lung fibrosis (RILF).
| M.Wt | 326.49 | |
| Formula | C17H34N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sang Yeon Kim, et al. Int J Mol Sci. 2023 Nov 13;24(22):16265.
2. Chung Hwan Hong, et al. Cell Mol Gastroenterol Hepatol. 2022;13(3):925-947.
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