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Chemical Structure : NY0116
Catalog No.: PC-35773Not For Human Use, Lab Use Only.
NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays.
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NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays.
NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.
NY0116 significantly decreased high-fat diet consumption in vivo after acute administration, decreased body weight and more specifically, decreased the percentage of visceral adipose tissue (VAT) in obese mice after repeated administration.
| M.Wt | 345.446 | |
| Formula | C22H23N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sampson CM, et al. Pharmacol Res Perspect. 2018 Aug 23;6(5):e00425.
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