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NY0116

Chemical Structure : NY0116

CAS No.: 1003000-59-6

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NY0116 (NY 0116, NY-0116)

Catalog No.: PC-35773Not For Human Use, Lab Use Only.

NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NY0116 (NY 0116) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 27.76 uM for hNMUR1 and 13.61 uM for hNMUR2 in intracellular calcium mobilization assays.
    NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.
    NY0116 significantly decreased high-fat diet consumption in vivo after acute administration, decreased body weight and more specifically, decreased the percentage of visceral adipose tissue (VAT) in obese mice after repeated administration.

    Physicochemical Properties

    M.Wt 345.446
    Formula C22H23N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(2-(trityloxy)ethyl)guanidine

    References

    1. Sampson CM, et al. Pharmacol Res Perspect. 2018 Aug 23;6(5):e00425.

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