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NY0128

Chemical Structure : NY0128

CAS No.: 1003000-60-9

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NY0128 (NY 0128, NY-0128)

Catalog No.: PC-35774Not For Human Use, Lab Use Only.

NY0128 (NY 0128) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 29.99 uM for hNMUR1 and 10.30 uM for hNMUR2 in intracellular calcium mobilization assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    NY0128 (NY 0128) is a small molecule neuromedin U receptor 2 (NMUR2) agonist with EC50 of 29.99 uM for hNMUR1 and 10.30 uM for hNMUR2 in intracellular calcium mobilization assays.
    NY0128 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.
    NY0128 significantly decreased high-fat diet consumption in vivo after acute administration, decreased body weight and more specifically, decreased the percentage of visceral adipose tissue (VAT) in obese mice after repeated administration.

    Physicochemical Properties

    M.Wt 359.473
    Formula C23H25N3O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(trityloxy)propyl)guanidine

    References

    1. Sampson CM, et al. Pharmacol Res Perspect. 2018 Aug 23;6(5):e00425.

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