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Chemical Structure : NY0128
Catalog No.: PC-35774Not For Human Use, Lab Use Only.
NY0128 (NY 0128) is a small molecule neuromedin U receptor 2 (NMUR2) with EC50 of 29.99 uM for hNMUR1 and 10.30 uM for hNMUR2 in intracellular calcium mobilization assays.
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NY0128 (NY 0128) is a small molecule neuromedin U receptor 2 (NMUR2) agonist with EC50 of 29.99 uM for hNMUR1 and 10.30 uM for hNMUR2 in intracellular calcium mobilization assays.
NY0128 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.
NY0128 significantly decreased high-fat diet consumption in vivo after acute administration, decreased body weight and more specifically, decreased the percentage of visceral adipose tissue (VAT) in obese mice after repeated administration.
| M.Wt | 359.473 | |
| Formula | C23H25N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Sampson CM, et al. Pharmacol Res Perspect. 2018 Aug 23;6(5):e00425.
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