NYX-1492 | PCSK9 inhibitor | Probechem Biochemicals

Chemical Structure : NYX-1492

NYX-1492 (PCSK-287, NYX1492)

Catalog No.: PC-21266Not For Human Use, Lab Use Only.

NYX-1492 is a small molecule PCSK9 inhibitor, blocks PCSK9 binding with the LDLR, attenuates inflammation in vascular cells and tissue-engineered blood vessels (TEBVs).

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Biological Activity

NYX-1492 is a small molecule PCSK9 inhibitor, blocks PCSK9 binding with the LDLR, attenuates inflammation in vascular cells and tissue-engineered blood vessels (TEBVs).
NYX-1492 reduces monocyte adhesion in P+ TEBVs with evidence of lowering secretion of VCAM-1 and TNF-α.

Physicochemical Properties

M.Wt	581.59
Formula	C31H28F5N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(3-((3-amino-4,4-difluoropiperidin-1-yl)methyl)-5-(6-(trifluoromethyl)pyridin-3-yl)phenyl)-5-methyl-4-phenylpicolinamide

References

1. Jounghyun H Lee, et al. APL Bioeng. 2023 Oct 16;7(4):046103.

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NYX-1492 (PCSK-287, NYX1492)

Biological Activity

Physicochemical Properties

References

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