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Chemical Structure : NYX-2925
Catalog No.: PC-20695Not For Human Use, Lab Use Only.
NYX-2925 (NYX2925) is a potent, specific NMDAR positive allosteric-modulator, facilitates [3H] MK-801 binding in all four human NMDAR2 subtypes with EC50 of 55 pM, 28 fM, 11 pM, and 55 pM for hNR2A, 2B, 2C, and 2D receptors, respectively.
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NYX-2925 (NYX2925) is a potent, specific NMDAR positive allosteric-modulator, facilitates [3H] MK-801 binding in all four human NMDAR2 subtypes with EC50 of 55 pM, 28 fM, 11 pM, and 55 pM for hNR2A, 2B, 2C, and 2D receptors, respectively.
NYX-2925 does not exhibit any significant affinity for a large panel of neuroactive receptors, including hERG receptors.
NYX-2925 increased MK-801 binding to human N-methyl-D-aspartate receptor NR2A-D subtypes expressed in HEK cells and enhanced N-methyl-D-aspartate receptor current and long-term potentiation (LTP) in rat hippocampal slices (100–500 nM).
NYX-2925 showed increased metaplasticity in a hippocampal LTP paradigm and structural plasticity 24 hours after administration (1 mg/kg p.o.).
NYX-2925, like rapastinel, activates an NMDA receptor-mediated synaptic plasticity process and may have therapeutic potential for a variety of NMDA receptor-mediated central nervous system disorders.
| M.Wt | 297.36 | |
| Formula | C14H23N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ghoreishi-Haack N, et al. J Pharmacol Exp Ther. 2018 Sep;366(3):485-497.
2. Khan MA, et al. Int J Neuropsychopharmacol. 2018 Mar 1;21(3):242-254.
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