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NYY-001

Chemical Structure : NYY-001

CAS No.: 2637469-51-1

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NYY-001 (NYY001)

Catalog No.: PC-25979Not For Human Use, Lab Use Only.

NYY-001 is a specific small molecule S-nitrosoglutathione reductase (GSNOR) inhibitor, selectively blocks the GSNOR-ERG (ETS-related gene) interaction, enhancespostischemic neovascularization and restored vascular permeability in the peripheral vasculature in STZ-induced type 1 diabetes and db/db type 2 diabetes mouse models.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NYY-001 is a specific small molecule S-nitrosoglutathione reductase (GSNOR) inhibitor, selectively blocks the GSNOR-ERG (ETS-related gene) interaction, enhancespostischemic neovascularization and restored vascular permeability in the peripheral vasculature in STZ-induced type 1 diabetes and db/db type 2 diabetes mouse models.

Physicochemical Properties

M.Wt 499.59
Formula C27H25N5O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(2-(4-(1H-imidazol-1-yl)phenyl)-5-(3-oxo-3-(2-oxothiazolidin-3-yl)propyl)-1H-pyrrol-1-yl)-3-methylbenzamide

References

1. Zhao S, et al. Sci Transl Med. 2025 Oct;17(818):eadn9216.

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