Chemical Structure : NZ-58
CAS No.:
1609523-20-7
NZ-58
Catalog No.: PC-26887Not For Human Use, Lab Use Only.
NZ-58 is a small molecule inhibitor of the HV1 voltage-gated proton channel with IC50 of 8.5 uM, also potently blocks voltage-gated Na+ and K+ channels at 50 uM, acts as a pan-VSD (voltage-sensor domains) modulator.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
NZ-58 is a small molecule inhibitor of the HV1 voltage-gated proton channel with IC50 of 8.5 uM, also potently blocks voltage-gated Na+ and K+ channels at 50 uM, acts as a pan-VSD (voltage-sensor domains) modulator.
NZ-58 induces complete inhibition of multiple ion channels, including VGICs NaV1.5, NaV1.2, NaV1.4, KV1.3, fast inactivation-removed KV1.4, KV1.5, KV11.1 (hERG), as well as the non-voltage-gated Kir2.1 and KCa3.1 channels, in whole-cell patch clamp at 50 uM.
Physicochemical Properties
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M.Wt
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401.35
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Formula
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C19H14F3N5O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(3-(2-amino-1H-imidazol-5-yl)phenyl)-5-(trifluoromethoxy)-1H-indole-2-carboxamide
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References
1. Geraldo Jorge Domingos, et al. Biomed Pharmacother. 2026 May 20:200:119530.
2. M. Piga, et al. J. Chem. Inf. Model. (2024)
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