NaV1.6 inhibitor Compound 103

Chemical Structure : NaV1.6 inhibitor Compound 103

Catalog No.: PC-25010Not For Human Use, Lab Use Only.

NaV1.6 inhibitor Compound 103 is a potent, selective voltage-gated sodium channel NaV1.6 inhibitor with IC50 of 61 nM, >400-fold selective over NaV1.1 and NaV1.5.

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Biological Activity

NaV1.6 inhibitor Compound 103 is a potent, selective voltage-gated sodium channel NaV1.6 inhibitor with IC50 of 61 nM, >400-fold selective over NaV1.1 and NaV1.5.

Physicochemical Properties

M.Wt	478.58
Formula	C22H24F2N4O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6-difluoro-3-methyl-N-(thiazol-4-yl)benzenesulfonamide

References

1. Patent WO2017201468 A1.

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