NaV1.7 inhibitor 31

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Chemical Structure : NaV1.7 inhibitor 31

Catalog No.: PC-23533Not For Human Use, Lab Use Only.

NaV1.7 inhibitor 31 is a potent and selective inhibitor of Nav1.7 with Ki/IC50 of 4.9 nM/13 nM (hNav1.7), >400-fold selective over hNav1.5.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NaV1.7 inhibitor 31 is a potent and selective inhibitor of Nav1.7 with Ki/IC50 of 4.9 nM/13 nM (hNav1.7), >400-fold selective over hNav1.5.
NaV1.7 inhibitor 31 shows>20-fold selectivity over Nav1.6, unfortunately, no selectivity against Nav1.1 and Nav1.2.
NaV1.7 inhibitor 31 (3-100 mg/kg) demonstrate robust analgesic effects on aconitine-induced nociception in IEM transgenic mice.

Physicochemical Properties

M.Wt	580.49
Formula	C30H33Cl2F2NO4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2R,3S,5R)-5-(5-cyclopropyl-4-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)-2-fluorobenzoyl)-3-fluoro-2-methylcyclopentane-1-carboxylic acid

References

1. Sun S, et al. Bioorg Med Chem Lett. 2024 Nov 21:130033.

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