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Chemical Structure : Nacubactam
CAS No.: 1452458-86-4
Catalog No.: PC-62613Not For Human Use, Lab Use Only.
Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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Nacubactam (OP 0595, RG 6080, RO 7079901) is a diazabicyclooctane that inhibits class A and C β-lactamases with IC50 of <1 uM, also acts as a PBP2-active antibacterial.
Nacubactam exhibits MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2.
Nacubactam has MICs of 1-4 mg/ml for Escherichia coli, Enterobacter, Citrobacter and Klebsiella spp.
Nacubactam increases the antibacterial activity of cefepime in both in vitro and in vivo.
| M.Wt | 324.31 | |
| Formula | C9H16N4O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2S, 5R)-N-(2-Aminoethoxy)-7-oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide |
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1. Morinaka A, et al. J Antimicrob Chemother. 2015 Oct;70(10):2779-86.
2. Livermore DM, et al. J Antimicrob Chemother. 2015 Nov;70(11):3032-41.
3. Livermore DM, et al. Antimicrob Agents Chemother. 2015 Nov 9;60(1):554-60.
4. Morinaka A, et al. J Antibiot (Tokyo). 2017 Mar;70(3):246-250.
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