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Chemical Structure : Naltrexone
CAS No.: 16590-41-3
Catalog No.: PC-45979Not For Human Use, Lab Use Only.
Naltrexone is a potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $48 | In stock | |
| 100 mg | $68 | In stock | |
| 250 mg | $98 | In stock | |
| 1 g | Get quote |
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Naltrexone is a potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
Naltrexone also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs.
Naltrexone is a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).
| M.Wt | 341.4009 | |
| Formula | C20H23NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5α)- |
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1. Codd EE, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70.
2. Cant R, et al. Front Immunol. 2017 Jul 11;8:809.
3. Selfridge BR, et al. J Med Chem. 2015 Jun 25;58(12):5038-52.
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