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Chemical Structure : Naltrexone hydrochloride
CAS No.: 16676-29-2
Catalog No.: PC-45978Not For Human Use, Lab Use Only.
A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 250 mg | $72 | In stock | |
| 500 mg | Get quote |
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A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).
Alcoholism
Approved
| M.Wt | 377.8618 | |
| Formula | C20H24ClNO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 33 mg/mL |
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| Chemical Name/SMILES |
Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, hydrochloride (1:1), (5α)- |
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1. Codd EE, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70.
2. Cant R, et al. Front Immunol. 2017 Jul 11;8:809.
3. Selfridge BR, et al. J Med Chem. 2015 Jun 25;58(12):5038-52.
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