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Chemical Structure : Naphthol AS-E
CAS No.: 92-78-4
Catalog No.: PC-61256Not For Human Use, Lab Use Only.
Naphthol AS-E is a cell-permeable inhibitor of the KIX-KID interaction and CREB-mediated gene transcription (IC50=2.26 uM).
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Naphthol AS-E is a cell-permeable inhibitor of the KIX-KID interaction and CREB-mediated gene transcription (IC50=2.26 uM).
Naphthol AS-E is the first KIX-binding small molecule to inhibit CREB-dependent gene transcription in living cells with IC50 in the low-uM range and a novel template for inhibiting protein-protein interactions.
| M.Wt | 297.738 | |
| Formula | C17H12ClNO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(4-chlorophenyl)-3-hydroxy-2-naphthamide |
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1. Jiang M, et al. J Med Chem. 2012 Apr 26;55(8):4020-4.
2. Li BX, et al. Chembiochem. 2009 Nov 23;10(17):2721-4.
3. Best JL, et al. Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17622-7.
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