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Naptumomab

Chemical Structure : Naptumomab

CAS No.:

Naptumomab (Anti-human 5T4 mAb, human IgG1-Kappa)

Catalog No.: PC-Ab1027Not For Human Use, Lab Use Only.

Naptumomab is a fusion protein containing the Fab-fragment of an antibody that targets the tumor-associated 5T4 antigen. Naptumomab activates T lymphocytes and targets them to the 5T4-expressing tumors, resulting in massive effector lymphocyte infiltration into the tumor and tumor cell killing. 5T4 (trophoblast glycoprotein, TPBG) is a transmembrane tumor antigen expressed on more than 90% of primary renal cell carcinomas (RCC) and a wide range of human carcinomas but not on most somatic adult t

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Naptumomab is a fusion protein containing the Fab-fragment of an antibody that targets the tumor-associated 5T4 antigen. Naptumomab activates T lymphocytes and targets them to the 5T4-expressing tumors, resulting in massive effector lymphocyte infiltration into the tumor and tumor cell killing. 5T4 (trophoblast glycoprotein, TPBG) is a transmembrane tumor antigen expressed on more than 90% of primary renal cell carcinomas (RCC) and a wide range of human carcinomas but not on most somatic adult tissues.

Physicochemical Properties

M.Wt
Formula Human IgG1-Kappa
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

References

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