Catalog No.: PC-45722Not For Human Use, Lab Use Only.
Naquotinib (ASP-8273) is a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).
Naquotinib (ASP-8273) mesylateis a potent, irreversible, mutant-selective inhibitor of EGFR (IC50=8-33 nM for (L858R, exon 19 deletion, L858R/T790M, and del19/T790M)).
Naquotinib (ASP-8273) is more potently than that of WT EGFR (IC50= 230 nM).
Naquotinib (ASP-8273) shows activity in mutant EGFR cell line which is resistant to other EGFR TKIs including AZD9291 and CO-1686.
