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Chemical Structure : Naspm
CAS No.: 122306-11-0
Catalog No.: PC-43075Not For Human Use, Lab Use Only.
Naspm is a selective antagonist of Ca2+-permeable AMPA receptors, blocks GluR2-lacking AMPARs, suppresses current responses induced by kainate in type II neurons with IC50 of 0.33 uM.
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| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
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Naspm is a selective antagonist of Ca2+-permeable AMPA receptors, blocks GluR2-lacking AMPARs, suppresses current responses induced by kainate in type II neurons with IC50 of 0.33 uM.
Naspm greatly reduces the late rise in intracellular free Zn(2+) in postischemic CA1 neurons and affords partial protection against ischemia-induced cell death, protects against ischemia-induced death of CA1 neurons in vivo.
Naspm selectively suppresses the inwardly rectifying and Ca(2+)-permeable AMPA receptors expressed in type II neurons, has no effect on AMPA receptors in type I neurons.
| M.Wt | 370.5316 | |
| Formula | C22H34N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Naphthaleneacetamide, N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]- |
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1. Noh KM, et al. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12230-5.
2. Nilsen A, et al. J Am Chem Soc. 2007 Apr 25;129(16):4902-3.
3. Hausknecht K, et al. Neuropsychopharmacology. 2015 Mar;40(4):893-905.
4. Chen T, et al. Mol Brain. 2014 Oct 31;7:76.
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