Nav1.5 inhibitor KH2

Chemical Structure : Nav1.5 inhibitor KH2

Catalog No.: PC-27210Not For Human Use, Lab Use Only.

Nav1.5 inhibitor KH2 is an effective Nav1.5 inhibitor with IC50 of 1.38 uM, reduces cardiac conduction.

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Biological Activity

Nav1.5 inhibitor KH2 is an effective Nav1.5 inhibitor with IC50 of 1.38 uM, reduces cardiac conduction.
KH2 significantly lowered acitivity against different Nav subtypes as hNav1.2 (IC50 = 5.72 μM), hNav1.4 (IC50 = 5.38 μM), hNav1.7 (IC50 = 7.61 μM), and hNav1.9 (IC50 = 9.73 μM).
KH2 reduced the conduction velocity of the left atrium in isolated rat hearts.
KH2 could modulate the conduction velocity of both atria and ventricles by blocking sodium channels, thereby altering the processes of depolarization and repolarization in the heart.

Physicochemical Properties

M.Wt	642.21
Formula	C36H36ClN3O4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(4-benzylpiperidin-1-yl)propyl)-10-(3-chlorobenzyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5,5-dioxide

References

1. Wang YY, et al. Acta Pharmacol Sin. 2026 Apr;47(4):990-998.