Nav1.7 inhibitor WN2-R

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Chemical Structure : Nav1.7 inhibitor WN2-R

Catalog No.: PC-24050Not For Human Use, Lab Use Only.

Nav1.7 inhibitor WN2-R is a novel potent, selective Nav1.7 antagonist with IC50 of 24.7 nM within the VSDIV pocket of Nav1.7.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Nav1.7 inhibitor WN2-R is a novel potent, selective Nav1.7 antagonist with IC50 of 24.7 nM within the VSDIV pocket of Nav1.7.
WN2-R binds to the intended VSDIV pocket of Nv1.7.
WN2-R (10 uM) completely inhibits the native Na+ current while having almost no effect on the native K+ and Ca2+ currents in DRG neurons.
WN2-R exhibits impressive analgesic effects in acute and chronic inflammatory pain, as well as neuropathic pain models in mice.

Physicochemical Properties

M.Wt	457.59
Formula	C29H32FN3O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-N-(2-(dimethylamino)ethyl)-3-(4-fluorophenyl)-3-(1-(4-methylbenzyl)-1H-indol-3-yl)propanamide

References

1. Wang G, et al. Research (Wash D C). 2025 Jan 29;8:0599.

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